Postpartum Ovarian Vein Thrombosis

Postpartum ovarian vein thrombosis carries a significant risk of morbidity and mortality if not recognized early and managed appropriately

SOM-based behavioral analysis for virtualized network functions

In this paper, we propose a mechanism based on Self-Organizing Maps for analyzing the resource consumption behaviors and detecting possible anomalies in data centers for Network Function Virtualization (NFV). Our approach is based on a joint analysis of two historical data sets available through two separate monitoring systems: system-level metrics for the physical and virtual machines obtained from the monitoring infrastructure, and application-level metrics available from the individual virtualized network functions. Experimental results, obtained by processing real data from one of the NFV data centers of the Vodafone network operator, highlight some of the capabilities of our system to identify interesting points in space and time of the evolution of the monitored infrastructure

Behavioral Analysis for Virtualized Network Functions : A SOM-based Approach

In this paper, we tackle the problem of detecting anomalous behaviors in a virtualized infrastructure for network function virtualization, proposing to use self-organizing maps for analyzing historical data available through a data center. We propose a joint analysis of system-level metrics, mostly related to resource consumption patterns of the hosted virtual machines, as available through the virtualized infrastructure monitoring system, and the application-level metrics published by individual virtualized network functions through their own monitoring subsystems. Experimental results, obtained by processing real data from one of the NFV data centers of the Vodafone network operator, show that our technique is able to identify specific points in space and time of the recent evolution of the monitored infrastructure that are worth to be investigated by a human operator in order to keep the system running under expected conditions

iALMA Cryofacility Dry Run Report

The iALMA Cryofacility consist of a 2x1 squared meters surface chamber that will permit to test the ALMA band 2+3 cartridge at operational conditions. The Cryofacility is setup at the CryoWaves Lab at INAF/IASF-Bologna

N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism

Similar to canine inflammatory enteropathy, inflammatory bowel disease (IBD) is a chronic idiopathic condition characterized by remission periods and recurrent flares in which diarrhea, visceral pain, rectal bleeding/bloody stools, and weight loss are the main clinical symptoms. Intestinal barrier function alterations often persist in the remission phase of the disease without ongoing inflammatory processes. However, current therapies include mainly anti-inflammatory compounds that fail to promote functional symptoms-free disease remission, urging new drug discoveries to handle patients during this step of the disease. ALIAmides (ALIA, autacoid local injury antagonism) are bioactive fatty acid amides that recently gained attention because of their involvement in the control of inflammatory response, prompting the use of these molecules as plausible therapeutic strategies in the treatment of several chronic inflammatory conditions. N-palmitoyl-D-glucosamine (PGA), an under-researched ALIAmide, resulted in being safe and effective in preclinical models of inflammation and pain, suggesting its potential engagement in the treatment of IBD. In our study, we demonstrated that micronized PGA significantly and dose-dependently reduces colitis severity, improves intestinal mucosa integrity by increasing the tight junction proteins expression, and downregulates the TLR-4/NLRP3/iNOS pathway via PPAR-α receptors signaling in DNBS-treated mice. The possibility of clinically exploiting micronized PGA as support for the treatment and prevention of inflammation-related changes in IBD patients would represent an innovative, effective, and safe strategy

factors underlying the development of chronic temporal lobe epilepsy in autoimmune encephalitis

Abstract Purpose Limbic encephalitis (LE) is an autoimmune condition characterized by amnestic syndrome, psychiatric features and seizures. Early diagnosis and prompt treatment are crucial to avoid long-term sequelae, including psycho-cognitive deficits and persisting seizures. The aim of our study was to analyze the characteristics of 33 LE patients in order to identify possible prognostic factors associated with the development of chronic epilepsy. Methods This is a retrospective cohort study including adult patients diagnosed with LE in the period 2010–2017 and followed up for ≥12 months. Demographics, seizure semiology, EEG pattern, MRI features, CSF/serum findings were reviewed. Results All 33 LE patients (19 M/14F, mean age 61.2 years) presented seizures. Thirty subjects had memory deficits; 22 presented behavioural/mood disorders. Serum and/or CSF auto-antibodies were detected in 12 patients. In 31 subjects brain MRI at onset showed typical alterations involving temporal lobes. All patients received immunotherapy. At follow-up, 13/33 had developed chronic epilepsy; predisposing factors included delay in diagnosis (p = .009), low seizure frequency at onset (p = .02), absence of amnestic syndrome (p = .02) and absence/rarity of inter-ictal epileptic discharges on EEG (p = .06). Conclusions LE with paucisymptomatic electro-clinical presentation seemed to be associated to chronic epilepsy more than LE presenting with definite and severe "limbic syndrome"

Long-Term Relationship Between Atrial Fibrillation, Multimorbidity and Oral Anticoagulant Drug Use

Objectives: To analyze the relationship between atrial fibrillation (AF) and Charlson comorbidity index (CCI) in a population-based cohort study over a long-term follow-up period, in relation to oral anticoagulant (OAC) prescriptions and outcomes. Patients and Methods: We used data from the administrative health databases of Lombardy. All patients with AF and age 40 years and older and who were admitted to the hospital in 2002 were considered for analysis and followed up to 2014. AF diagnosis and CCI were established according to codes from the International Classification of Diseases, Ninth Revision. Results: In 2002, 24,040 patients were admitted with a diagnosis of AF. CCI was higher in patients with AF than in those without AF (1.8\ub12.1 vs 0.2\ub10.9; P<.001). Over 12 years of follow-up, AF was associated with an increased risk of higher CCI (beta coefficient, 1.69; 95% CI, 1.67-1.70). In patients with AF, CCI was inversely associated with OAC prescription at baseline (P<.001) and at the end of the follow-up (P=.03). Patients with AF and a high CCI ( 654) had a higher cumulative incidence of stroke, major bleeding, and all-cause death (all P<.001), compared with those with low CCI (range, 0-3). Adjusted Cox regression analysis revealed that time-dependent continuous CCI was associated with an increased risk for stroke, major bleeding, and all-cause death (all P<.001). Conclusions: In hospitalized patients, AF is associated with an increase in CCI that is inversely associated with OAC prescriptions during follow-up. CCI is independently associated with an increased risk of stroke, major bleeding, and all-cause death

Acute thrombosis of the superior mesenteric artery in a 39-year-old woman with protein-S deficiency: a case report

<p>Abstract</p> <p>Introduction</p> <p>Acute thromboembolic occlusion of the superior mesenteric artery is a condition with an unfavorable prognosis. Treatment of this condition is focused on early diagnosis, surgical or intravascular restoration of blood flow to the ischemic intestine, surgical resection of the necrotic bowel and supportive intensive care. In this report, we describe a case of a 39-year-old woman who developed a small bowel infarct because of an acute thrombotic occlusion of the superior mesenteric artery, also involving the splenic artery.</p> <p>Case presentation</p> <p>A 39-year-old Caucasian woman presented with acute abdominal pain and signs of intestinal occlusion. The patient was given an abdominal computed tomography scan and ultrasonography in association with Doppler ultrasonography, highlighting a thrombosis of the celiac trunk, of the superior mesenteric artery, and of the splenic artery. She immediately underwent an explorative laparotomy, and revascularization was performed by thromboendarterectomy with a Fogarty catheter. In the following postoperative days, she was given a scheduled second and third look, evidencing necrotic jejunal and ileal handles. During all the surgical procedures, we performed intraoperative Doppler ultrasound of the superior mesenteric artery and celiac trunk to control the arterial flow without evidence of a new thrombosis.</p> <p>Conclusion</p> <p>Acute mesenteric ischemia is a rare abdominal emergency that is characterized by a high mortality rate. Generally, acute mesenteric ischemia is due to an impaired blood supply to the intestine caused by thromboembolic phenomena. These phenomena may be associated with a variety of congenital prothrombotic disorders. A prompt diagnosis is a prerequisite for successful treatment. The treatment of choice remains laparotomy and thromboendarterectomy, although some prefer an endovascular approach. A second-look laparotomy could be required to evaluate viable intestinal handles. Some authors support a laparoscopic second-look. The possibility of evaluating the arteriotomy, during a repeated laparotomy with a Doppler ultrasound, is crucial to show a new thrombosis. Although the prognosis of acute mesenteric ischemia due to an acute arterial mesenteric thrombosis remains poor, a prompt diagnosis, aggressive surgical treatment and supportive intensive care unit could improve the outcome for patients with this condition.</p

The 2016 Campobasso MW 4.3 seismic sequence

Alle 18.55 UTC del 16 gennaio 2016 è stato registrato dalla Rete Sismica Nazionale1 (RSN, http://doi.org/10.13127/SD/X0FXNH7QFY) dell’Istituto Nazionale di Geofisica e Vulcanologia (INGV) un terremoto di magnitudo locale (M ) 4.1 (magnitudo momento M 4.3) ben risentito in gran parte delle province di Campobasso e di Isernia e in alcune zone delle province limitrofe di Caserta, Benevento e Foggia. L’evento, localizzato a circa 6 km di distanza dal capoluogo molisano e ad una profondità prossima ai 10 km, è stato preceduto durante la giornata da una decina di eventi, il più significativo dei quali è stato di ML 2.9. La sequenza sismica sviluppatasi nei giorni successivi si colloca in un’area caratterizzata da una pericolosità sismica molto elevata e a circa 20 km a nord-est dalla sequenza sismica iniziata il 29 dicembre 2013 con un evento di ML 4.9 (MW 5.0 [De Gori et al., 2014]). Considerate le criticità che il sistema di sorveglianza sismica attivo H24/7 presso la sede INGV di Roma ha iniziato a patire nei giorni successivi a causa di cattive condizioni meteo, è stata predisposta in collaborazione con l’Agenzia della Protezione Civile della Regione Molise l’installazione di una stazione sismica temporanea a sei canali. L’installazione si è svolta nell’ambito del Coordinamento delle reti sismiche mobili INGV (Sismiko [Margheriti et al., 2014; Moretti et al., 2016]) ed è stata sufficiente per garantire la continuità del servizio di sorveglianza sismica, come richiesto nella Convenzione vigente2 tra l’INGV e il Dipartimento della Protezione Civile (DPC). La sequenza è stata analizzata con diverse tecniche di localizzazione, i cui risultati sono stati messi a confronto nel corrente lavoro.Published1-324IT. Banche datiJCR Journalope

“Messina 1908-2008”: Progetto di ricerca integrato per l’area Calabro - Peloritana. L’esperimento di sismica passiva

Il 28 dicembre 1908 un forte terremoto colpì duramente le città di Messina e di Regg io Calabria e molteplici centri abitati limitrofi. L’evento sismico di Mw=7.1 generò un maremoto e causò circa 100.000 morti. Durante il 2008 numerose sono state le iniziative per rievocare tale importante terremoto che è ricordato nella storia come il più forte avvenuto in Italia. Tra le iniziative promosse dall’Istituto Nazionale di Geofisica e Vulcanologia vi è il progetto di ricerca “Messina 1908-2008” le cui finalità sono far convergere i dati sismici e geodetici g ià a disposizione dei singoli gruppi di ricerca in un’unica banca dati e nel contempo promuoverne l’acquisizione di nuovi. In questo rapporto è descritto l’esperimento di sismica passiva integrato mare-terra iniziato ad ottobre 2007 e ter minato nel gennaio 2010 avente l’obiettivo di acquisire nuovi dati di alta qualità e dettaglio per ottenere una migliore definizione della microsismicità locale. Ciò consentirà di raggiungere una migliore comprensione di come inter ag iscano il processo di subduzione e le dinamiche superficiali nell’area dell’arco Calabro Peloritano ed in particolare nello stretto di Messina